01
Apr
Reading time - 11 mins
Testosterone - What makes testosterone so important for someone is who is training and exerting their body, wanting to recover and improve/progress towards their goals? Let’s take a look at what testosterone does in the body.
Testosterone Physiology
Testosterone, as we know, is the primary male hormone, responsible for the production of typical male sex characteristics that are present from week 7 in the womb. From this stage, the testosterone developed in the testis goes on to be converted to Dihydrotestosterone (DHT) to develop the prostate and the external genitalia.
From here we see more of the obvious male sex traits develop into puberty and beyond:
Entering the stages of puberty, the hypothalamic-pituitary-gonadal axis plays a crucial role in regulating surging testosterone levels and gonadal function. The hypothalamus is like the old-school telephone operator that connects the caller to the person receiving the call; it’s receiving signals from all sensory information 24/7. From here it sorts the information and relays the correct action required.

In the instance of testosterone production, the hypothalamus secretes what is called gonadotropin-releasing hormone (GnRH), this gets directed to the anterior pituitary gland which then secrets luteinizing hormone (LH) and Follicle-stimulating hormone (FSH). These two latter hormones are gonadotropic hormones, meaning that they are transported via the blood and act only on specifically targeted receptors on the Leydig cells of the gonads to produce testosterone.
Testosterone Feedback Loops
The body is a very efficient machine, it works constantly from communication feedback to pivot, adjust and maintain balance. The same is said for the production of testosterone, this is built into what is known as a ‘negative feedback loop; meaning that testosterone can limit its own production. How? High levels of testosterone in the blood relay feedback to our control centre to notify that the secretion of GnRH can subside until required again, the hypothalamus then communicates this to our anterior pituitary to be less responsive to the stimulation of GnRH. This sounds worse than it actually is, in reality, GnRH is secreted in pulses every 1-3 hours, so these feedback loops delays or deficits are few and far between. [2]
Not all testosterone is free to do as it pleases on its own in the body. There is a small amount of ‘free testosterone available, the rest of the total testosterone in the body is bound with plasma proteins, or what is commonly known as ‘sex-hormone-binding-globulin’ and albumin, which is just a form of protein made by the liver. The small measure of free-testosterone acts on more specific areas of the blood tissue such as:
At a cellular level in the body, testosterone is converted over to DHT via an enzyme process involving 5-alpha reductase. Binding to cell receptors and regulating protein expression – this is the way in which various forms of proteins are synthesized in the body depending on the functional need of our cells (it’s a lot more technical than that, but we will skip out on the lengthy description of DNA and RNA in this instance).
As we mentioned earlier, testosterone is self-regulating – when we have a surge of testosterone that is too high, we can get more of a trickle overflow into Dihydrotestosterone (DHT) conversion, which is often not a bad thing, we still need DHT for critical processes in the body and DHT is actually known to be around several times more potent than testosterone [3] – however, too much of one thing is not always ideal. Higher conversion of test to DHT is often shown in male pattern baldness and acne. However, excess DHT effects are more commonly seen in women as hirsutism, acne, and absence of menstrual cycle.
Testosterone as we age

As men age, testosterone production does begin to naturally decline, most often men reach their peak level of testosterone production in their mid to late 20’s and from here it slowly declines. Less commonly referred to as ‘Andropause’ is the state in which testosterone declines more rapidly once men reach their 50s and by the age of 80 most men sit at about 20-50% of their total peak testosterone levels of their younger years. [4]
This can lead to a symptom such as seen in the small-scale study of 53 men aged above 50 which reported: [4]
Low testosterone serum levels have since been associated with male andropause syndrome. [4]
Taking care of your Testosterone
There are many beneficial factors that support healthy testosterone production and serum levels, those include:
Ares by ATP Science, recognised by the Therapeutic Goods Administration in Australia to:
Paired with your essential mineral micronutrients such as those found in ZMAG also recognised by the Therapeutic Goods Administration in Australia to:
All of these elements allow for a lesser tensile state when we may be stuck in “fight and flight” mode. In this fight and flight mode, testosterone production is often less of a priority [6], and by returning to a “rest and digest” state you can support the body to maintain the communication and feedback loops needed to maintain healthy testosterone levels.
Basaria S. Reproductive aging in men. Endocrinol Metab Clin North Am. 2013 Jun;42(2):255-70.
[Plant TM, Marshall GR. The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocr Rev. 2001 Dec;22(6):764-86.
Grino PB, Griffin JE, Wilson JD. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology. 1990 Feb;126(2):1165-72. doi: 10.1210/endo-126-2-1165. PMID: 2298157
Wu CY, Yu TJ, Chen MJ. Age related testosterone level changes and male andropause syndrome. Chang Gung Med J. 2000 Jun;23(6):348-53. PMID: 10958037.
Leproult, R., & Van Cauter, E. (2011). Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA, 305(21), 2173–2174. https://doi.org/10.1001/jama.2011.710
Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016). Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. Comprehensive Physiology, 6(2), 603–621. https://doi.org/10.1002/cphy.c150015
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